Caprie study ppt

A randomised, blinded, trial of clopidogrel versus aspirin ...

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of the clinical subgroups, over 3 years and to terminate the study aggregation equivalent to that of ticlopidine, 250 mg twice daily. CAPRIE was a randomised clinical trial to assess the potential benefit of clopidogrel, compared with aspirin, in reducing the risk of ischaemic stroke, myocardial infarction, or vascular death in patients with recent

A randomised, blinded, trial of clopidogrel versus aspirin ...

Stroke and the statistics of the aspirin/clopidogrel ...

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study. The surrounding confusion is a product of these shortcomings in information. We will first review the three studies CAPRIE, CURE and MATCH. We then see if a more recent fourth study clarified concerns and uncertainties about the first three. A brief overview of the first three studies is necessary to

Stroke and the statistics of the aspirin/clopidogrel ...

CAPRIE trial - The Lancet

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The CAPRIE study1 (Nov 16, p 1329) shows that clopidogrel reduced by 8·7% the risk of cardiovascular events in the whole population, but this effect was not equally distributed in the three subgroups (ischaemic stroke, recent myocardial infarction [MI], and peripheral arterial disease).

CAPRIE trial - The Lancet

Results of the CAPRIE trial: efficacy and safety of ...

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Author information: (1)Cardiovascular Division, Brigham and Women's Hospital, Boston, MA 02115, USA. The recent CAPRIE trial (clopidogrel versus aspirin in patients at risk of ischaemic events) compared clopidogrel with aspirin in reducing the risk of vascular events in 19,185 patients with clinical ...

Results of the CAPRIE trial: efficacy and safety of ...

Plavix® Consultants Kit Blue - Clinical Trial Results

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CAPRIE Study Risk Reduction in MI Outcome Events (Fatal and Nonfatal MI) Event Rate for MI (fatal or nonfatal) 19.2% Relative Risk Reduction (P=0.008)2* Aspirin1 3.6% PLAVIX1 2.9% * Based on post hoc analysis of individual outcome events (N=19,185). 1 Data on file, Sanofi Pharmaceuticals, Inc.

Plavix® Consultants Kit Blue - Clinical Trial Results

Clopidogrel and Aspirin versus Aspirin Alone for the ...

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In the original, large-scale Clopidogrel versus Aspirin in Patients at Risk of Ischaemic Events (CAPRIE) trial, 13 clopidogrel alone was found to be superior to aspirin alone in reducing the risk ...

Clopidogrel and Aspirin versus Aspirin Alone for the ...

PPT - CAPRIE Study Risk Reduction in MI Outcome Events ...

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CAPRIE Study Risk Reduction in MI Outcome Events (Fatal and Nonfatal MI). 19.2%. Event Rate for MI (fatal or nonfatal). ... CAPRIE Study Risk Reduction in MI Outcome Events ... CAPRIE Study Risk Reduction in MI Outcome Events (Fatal and Nonfatal MI) - PowerPoint PPT Presentation

PPT - CAPRIE Study Risk Reduction in MI Outcome Events ...

Effects of Clopidogrel in Addition to Aspirin in Patients ...

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Study Design. We undertook a randomized, double-blind, placebo-controlled trial comparing clopidogrel with placebo in patients who presented with acute coronary syndromes without ST-segment elevation.

Effects of Clopidogrel in Addition to Aspirin in Patients ...

A randomised, blinded, trial of clopidogrel versus aspirin ...

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11/16/1996 · METHODS: CAPRIE was a randomised, blinded, international trial designed to assess the relative efficacy of clopidogrel (75 mg once daily) and aspirin (325 mg once daily) in reducing the risk of a composite outcome cluster of ischaemic stroke, myocardial infarction, or vascular death; their relative safety was also assessed.

A randomised, blinded, trial of clopidogrel versus aspirin ...

Clopidogrel PPT |authorSTREAM

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Clopidogrel PPT - authorSTREAM Presentation Go Premium | ... CLINICAL TRIALS OF CLOPIDOGREL CAPRIE TRIAL Clopidogrel versus Aspirin in Patients at Risk of Ischemic Events. ... and sustained long-term benefit throughout the entire 12 month study period in the CURE study:6 a 20% relative risk reduction in ischemic events with long-term use(up to ...

Clopidogrel PPT |authorSTREAM

CURE - Clinical Trial Results

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PCI-CURE PCI PLACEBO + ASA * CLOPIDOGREL + ASA * 30 days post PCI End of follow-up Up to 12 months after randomization Open-label thienopyridine Pretreatment Open-label thienopyridine Pretreatment N = 2,658 patients undergoing PCI * In combination with standard therapy N = 1345 N = 1313 CURE PCI-CURE R Mehta, SR. et al for the CURE Trial ...

CURE - Clinical Trial Results

PowerPoint Presentation

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CHARISMA StudyPrimary Efficacy Results (MI/Stroke/CV Death) by Prespecified Entry Category. MonotherapyClopidogrel vs Aspirin in Patients at Risk for Ischemic Events (CAPRIE) REACH Data. Long-Term Dual Antiplatelet Therapy After MI? TRILOGY ACS Post Hoc Analysis .

PowerPoint Presentation

PowerPoint Presentation

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Christopher Cannon, M.D. TIMI Study Group Cardiovascular Division Brigham and Women’s Hospital Boston, MA 2 Phases of ACS Treatment ACC/AHA UA/NSTEMI Guidelines: Smoking cessation Achieve optimal weight Daily exercise AHA Diet HTN control BP < 130/85 Tight control of glucose in DM Statin for LDL > 130 mg/dL.

PowerPoint Presentation

PPT - CAPRIE: Clopidogrel versus Aspirin in Patients at ...

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10/31/2014 · CAPRIE: Clopidogrel versus Aspirin in Patients at risk of Ischemic Events. Purpose To assess the relative efficacy of the antiplatelet drugs clopidogrel and aspirin in reducing the risk of thrombotic events in patients with atherosclerotic disease. Reference Slideshow 6008184 by...

PPT - CAPRIE: Clopidogrel versus Aspirin in Patients at ...

PPT – The CREDO Trial Clopidogrel for the Reduction of ...

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The PowerPoint PPT presentation: "The CREDO Trial Clopidogrel for the Reduction of Events During Observation Results" is the property of its rightful owner. Do you have PowerPoint slides to share? If so, share your PPT presentation slides online with PowerShow.com.

PPT – The CREDO Trial Clopidogrel for the Reduction of ...

The importance of bioequivalence study: Focus on clopidogrel

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The importance of bioequivalence study: focus on clopidogrel . ... At least one pivotal study of clopidogrel, CAPRIE, used clopidogrel form 1. ... In this study, 18 copies of PLAVIX tablets ...

The importance of bioequivalence study: Focus on clopidogrel

Platelet-Oriented Inhibition in New TIA and Minor Ischemic ...

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10/7/2009 · Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Platelet-Oriented Inhibition in New TIA and Minor Ischemic ...

4-Key Findings From Caprie | Stroke | Aspirin

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Download as PPT, PDF, TXT or read online from Scribd. Flag for inappropriate content. Download

4-Key Findings From Caprie | Stroke | Aspirin

Combination Therapy With Clopidogrel and Aspirin | Stroke

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Clopidogrel was shown to be a safe and efficacious medication for secondary prevention of vascular events in the CAPRIE study. 3 In this trial, the benefit of clopidogrel over aspirin for the prevention of vascular events was a relative risk reduction of 8.7%. In addition, there was less major bleeding in the clopidogrel group, yielding a ...

Combination Therapy With Clopidogrel and Aspirin | Stroke

PPT – Clopidogrel in the LongTerm Management of Patients ...

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Clopidogrel in the Long-Term Management of Patients at Risk. of Atherothrombosis ... Stable angina Intermittent claudication. Atherothrombosis. CURE: Design1 ... – A free PowerPoint PPT presentation (displayed as a Flash slide show) on PowerShow.com - id: fac18-NjZlZ

PPT – Clopidogrel in the LongTerm Management of Patients ...

Review on trials of clopidogrel - SlideShare

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11/4/2014 · REVIEW ON TRIALS OF CLOPIDOGREL Richa Sharma ... daily for two years No difference in the composite endpoint of stroke,USA,MI and death between the two groups CAPRIE study, 1996 Clopidogrel 75 mg/d for a minimum of one year and a maximum of 3 years compared with Aspirin 325 mg/d in patients with atherosclerotic manifestations (ischemic stroke ...

Review on trials of clopidogrel - SlideShare

PLAVIX DESCRIPTION - Food and Drug Administration

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The CAPRIE trial was a 19,185-patient, 304-center, international, randomized, double-blind, parallel-group study comparing Plavix (75 mg daily) to aspirin (325 mg daily). The patients randomized had: 1) recent histories of myocardial infarction (within 35 days); 2) recent histories

PLAVIX DESCRIPTION - Food and Drug Administration

CHARISMA: Clopidogrel for High Atherothrombotic Risk and ...

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CHARISMA was largely based on the Clopidogrel versus Aspirin in Patients at Risk of Ischemic Events (CAPRIE) study, which reported that long-term administration of clopidogrel to patients with ...

CHARISMA: Clopidogrel for High Atherothrombotic Risk and ...

The COMMIT trial: Metoprolol and clopidogrel in patients ...

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Please click to read metoprolol study in The Lancet. Please click to read clopidogrel study in The Lancet. In-Depth [randomized, controlled study]: The COMMIT trial was a large, randomized, placebo-controlled trial with a 2×2 factorial design (metoprolol vs. placebo and clopidogrel plus aspirin vs. aspirin alone) involving 45,852 patients. On ...

The COMMIT trial: Metoprolol and clopidogrel in patients ...

COMPASS | COMprehensive Post-Acute Stroke Services

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3/5/2019 · The COMPASS Study is a pragmatic, randomized trial to investigate post-acute stroke care models that are aimed at improving patient functional outcomes and reducing hospital re-admissions.

COMPASS | COMprehensive Post-Acute Stroke Services

The Prospective Pioglitazone Clinical Trial in ...

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7/1/2004 · OBJECTIVE —The PROspective pioglitAzone Clinical Trial In macroVascular Events (PROactive) assesses the effect of pioglitazone, a peroxisome proliferator-activated receptor agonist, with anti-inflammatory and vascular properties, on the secondary prevention of macrovascular events in type 2 diabetes. RESEARCH DESIGN AND METHODS —PROactive is an on-going randomized, double …

The Prospective Pioglitazone Clinical Trial in ...

Recent Trial Overview - freewebs.com

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CAPRIE: Clopidogrel versus Aspirin in Patients at risk of Ischemic Events Purpose To assess the relative efficacy of the antiplatelet drugs clopidogrel and aspirin in reducing the risk of thrombotic events in patients with atherosclerotic disease. Reference CAPRIE Steering Committee.

Recent Trial Overview - freewebs.com

The Dual Antiplatelet Therapy Study (DAPT Study) - Full ...

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9/16/2009 · The DAPT Study is a double blind randomized controlled trial intended to determine the appropriate duration for dual antiplatelet therapy (the combination of aspirin and a second anti-clotting medication) as well as the safety and effectiveness of dual antiplatelet therapy to protect patients from ...

The Dual Antiplatelet Therapy Study (DAPT Study) - Full ...

Effect on platelet function of cilostazol, clopidogrel ...

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12/15/2005 · By stratifying patients into pre-defined subgroups with recent MI, recent stroke, and chronic PAD, the CAPRIE study group sought to determine whether pathophysiologic differences between acute versus chronic disease would impact the outcomes of the two drug therapies.

Effect on platelet function of cilostazol, clopidogrel ...

CAPRIE 2 | Stroke | Myocardial Infarction

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CAPRIE 2 - Download as PDF File (.pdf), Text File (.txt) or read online. Estudio Caprie

CAPRIE 2 | Stroke | Myocardial Infarction

Effects of pretreatment with clopidogrel and aspirin ...

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The PCI CURE study was designed to test the hypothesis that, in addition to aspirin, treatment with clopidogrel before PCI is superior to placebo in preventing major ischaemic events afterwards. The second objective of Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary ...

Effects of pretreatment with clopidogrel and aspirin ...

pharmacology notes_0678 - marginally superior to aspirin ...

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View Notes - pharmacology notes_0678 from NURSING 115 at University of California, Los Angeles. marginally superior to aspirin for primary prevention (CAPRIE study). Mechanism of action Clopidogrel

pharmacology notes_0678 - marginally superior to aspirin ...

Antiplatelet drugs (antithrombotics) - SlideShare

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7/5/2016 · Clopidogrel • Newer and more potent congener of Ticlodipine • MOA – same with Ticlodipine but safer and better tolerated • Studies: CAPRIE study - Slightly lower risk of ischaemic events than aspirin recipients for primary ischemic events – combination in checking restenosis in stent coronary • Kinetics: Prodrug – 50% absorption ...

Antiplatelet drugs (antithrombotics) - SlideShare

Understanding Clopidogrel's Interaction with CYP2C19 ...

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With the exception of the CAPRIE study, which compared outcomes in clopidogrel versus aspirin, the other four all studied concurrent use of clopidogrel and aspirin versus aspirin alone. All studies found a significant decrease in reoccurrence of ACS and PVD events with a regimen including clopidogrel.

Understanding Clopidogrel's Interaction with CYP2C19 ...

Clopidogrel - Wikipedia

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Clopidogrel, sold under the trade name Plavix among others, is an antiplatelet medication used to reduce the risk of heart disease and stroke in those at high risk. It is also used together with aspirin in heart attacks and following the placement of a coronary artery stent (dual antiplatelet therapy). It is taken by mouth. Onset of effects is about 2 hours and lasts for 5 days.

Clopidogrel - Wikipedia

The Japan Statin Treatment Against Recurrent Stroke (J ...

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The Japan Statin Treatment Against Recurrent Stroke (J-STARS): a multicenter, randomized, open-label, parallel -group study Masayasu Matsumoto1, Naohisa Hosomi1, Yoji Nagai 2, Tatsuo Kohriyama 3, Shiro Aoki 1, Chiaki Yokota 4, Kazuo Kitagawa5, Yasuo Terayama 6, Makoto Takagi7, Setsuro Ibayashi8, Masakazu Nakamura4, Hideki Origasa9, Masanori Fukushima2, Etsuro Mori10, Kazuo Minematsu4 ...

The Japan Statin Treatment Against Recurrent Stroke (J ...

Combined therapy with clopidogrel and aspirin ...

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Objective: Many thromboembolic events occur in patients taking aspirin. Dual therapy with aspirin and clopidogrel may prove effective at reduction of thromboembolic complications. However, the extent to which these two drugs interact may significantly increase the risk of bleeding in open surgery. Because of the increased use of combination antiplatelet therapy in populations with significant ...

Combined therapy with clopidogrel and aspirin ...

EVIDENCED-BASED MEDICINE REVIEW ESPRIT Trial

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*ESPRIT = European/Australasian Stroke Prevention in Reversible Ischaemia Trial ** Performance bias definition - Bias present in the intervention or care procedures or other study performance. Frequently this is a bias that can result when there are difference in care other than the intervention under study.

EVIDENCED-BASED MEDICINE REVIEW ESPRIT Trial
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