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Primary prevention of cardiovascular disease with ...

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Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial. Colhoun HM(1), Betteridge DJ, Durrington PN, Hitman GA, Neil HA, Livingstone SJ, Thomason MJ, Mackness MI, Charlton-Menys V, Fuller JH; CARDS investigators.

Primary prevention of cardiovascular disease with ...

Atorvastatin reduced major cardiovascular disease events ...

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Atorvastatin reduced major cardiovascular disease events in type 2 diabetes mellitus Colhoun HM, Betteridge DJ, Durrington PN, et al. Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial. Lancet 2004;364:685–96.

Atorvastatin reduced major cardiovascular disease events ...

Atorvastatin in the CARDS for diabetes - Medscape

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The Collaborative Atorvastatin Diabetes Study (CARDS), comparing treatment with atorvastatin (Lipitor ® , Pfizer Inc) with placebo in 2800 patients with type 2 diabetes but without overt heart ...

Atorvastatin in the CARDS for diabetes - Medscape

Atorvastatin reduced major cardiovascular disease events ...

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Atorvastatin reduced major cardiovascular disease events in type 2 diabetes mellitus Colhoun HM, Betteridge DJ, Durrington PN, et al. Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial. Lancet. 2004;364:685-96.

Atorvastatin reduced major cardiovascular disease events ...

Effects of Atorvastatin on Kidney Outcomes and ...

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behalf of the CARDS Investigators Background: We examined whether atorvastatin affects diabetic kidney disease and whether the effect of atorvastatin on cardiovascular disease (CVD) varies by kidney status in patients with diabetes. Study Design: The Collaborative Atorvastatin Diabetes Study (CARDS) randomized placebo-controlled trial.

Effects of Atorvastatin on Kidney Outcomes and ...

Design of the Collaborative AtoRvastatin Diabetes Study ...

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The Collaborative AtoRvastatin Diabetes Study (CARDS) is a multicentre, randomized, placebo-controlled, double-blind clinical trial of primary prevention of cardiovascular disease in patients with ...

Design of the Collaborative AtoRvastatin Diabetes Study ...

Primary prevention of cardiovascular disease with ...

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8/21/2004 · The aim of the Collaborative Atorvastatin Diabetes Study (CARDS) was to assess the effectiveness of 10 mg of atorvastatin daily versus placebo in the primary prevention of cardiovascular disease in patients with type 2 diabetes. The trial was stopped 2 years earlier than planned because of significant benefit at the second interim analysis.

Primary prevention of cardiovascular disease with ...

Atorvastatin in Patients with Type 2 Diabetes Mellitus ...

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Atorvastatin Diabetes Study (CARDS) reported a de-crease in deaths from cardiovascular causes among persons with type 2 diabetes mellitus in the ab-sence of marked renal insufficiency. 3

Atorvastatin in Patients with Type 2 Diabetes Mellitus ...

Effects of Atorvastatin on Kidney Outcomes and ...

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The detailed methods used in CARDS and main outcomes have been published previously. 3 x 3 Colhoun, H.M., Betteridge, D.J., Durrington, P.N. et al. Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): Multicentre randomised placebo-controlled trial. Lancet.

Effects of Atorvastatin on Kidney Outcomes and ...

Atorvastatin in Patients with Type 2 Diabetes Mellitus ...

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Colhoun HM, Betteridge DJ, Durrington PN, et al. Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS ...

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PDF Page #1 Canadian drug name. Genetic Implication. CAPITALS indicate life-threatening, underlines indicate most frequent. Strikethrough Discontinued. 1 atorvastatin (a-tore-va-stat-in) Lipitor Classification ... atorvastatin.1_2.pdf Created Date: 2/18/2014 7:25:39 AM ...

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2/2/2014 · Lipid lowering trials ppt 1. LIPID LOWERING TRIALS DR.NAVIN AGRAWAL 2. INTRODUCTION Earliest trials of lipid lowering with bile acid sequestrants In 1971, Akira Endo, a Japanese reasoned that certain microorganisms may produce inhibitors of HMG CoA enzyme to defend themselves, as mevalonate is a precursor of many substances required by organisms for the …

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Lipid lowering trials ppt - SlideShare

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Methods The Collaborative AtoRvastatin Diabetes Study (CARDS) is a multicentre, randomized, placebo-controlled, double-blind clinical trial of primary prevention of cardiovascular disease in patients with Type 2 diabetes. The primary objective is to investigate whether treatment with the hydroxymethylglutaryl coenzyme A reductase inhibitor ...

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Design of the Collaborative AtoRvastatin Diabetes Study ...

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Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): Multicentre randomised placebo-controlled trial

Design of the Collaborative AtoRvastatin Diabetes Study ...

(PDF) Primary prevention of cardiovascular disease with ...

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ORIGINAL INVESTIGATIONS Pathogenesis and Treatment of Kidney Disease Effects of Atorvastatin on Kidney Outcomes and Cardiovascular Disease in Patients With Diabetes: An Analysis From the Collaborative Atorvastatin Diabetes Study (CARDS) Helen M. Colhoun, MD,1 D. John Betteridge, PhD,2 Paul N. Durrington, MD,3 Graham A. Hitman, MD,4 H. Andrew W. Neil, DSc,5 Shona J. Livingstone, …

(PDF) Primary prevention of cardiovascular disease with ...

(PDF) Effects of Atorvastatin on Kidney Outcomes and ...

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We exam- ined predictors of stroke and the effect of atorvastatin on specific stroke subtypes in Type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS) [a trial of 2838 participants with mean low-density lipoprotein cholesterol < 4.14 mmol/l, no history of macrovascular disease and randomized to atorvastatin 10 mg daily or ...

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View Notes - ATORVASTATIN.pdf from MED CARDS 1 at Unitek College, Fremont. ACTIVE LEARNING TEMPLATE: Medication STUDENT NAME_ atorvastatin MEDICATION_ REVIEW MODULE CHAPTER_ agents CATEGORY ... As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get ...

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ATORVASTATIN.pdf - coursehero.com

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Lipitor ® (Atorvastatin Calcium) Tablets DESCRIPTION LIPITOR ® (atorvastatin calcium) is a synthetic lipid-lowering agent. Atorvastatin is an ... In the Collaborative Atorvastatin Diabetes Study (CARDS), the effect of LIPITOR (atorvastatin calcium) on cardiovascular disease (CVD) endpoints was assessed in …

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Lipitor - Food and Drug Administration

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Aim To describe baseline characteristics of patients in the Collaborative AtoRvastatin Diabetes Study (CARDS), a randomized, placebo-controlled trial of lipid lowering with atorvastatin 10 mg daily for the primary prevention of major cardiovascular events in patients with Type 2 diabetes.

Lipitor - Food and Drug Administration

Baseline characteristics in the Collaborative AtoRvastatin ...

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4/5/2003 · 1. Lancet. 2003 Apr 5;361(9364):1149-58. Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial.

Baseline characteristics in the Collaborative AtoRvastatin ...

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Heart Protection Study (HPS),14 the Collaborative Atorvastatin Diabetes Study (CARDS),15 the Anglo-Scandinavian Cardiac Outcomes Lipid Lowering Arm (ASCOT-LLA), 16 the Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack (ALLHAT) study,17 and the Management of Elevated Cholesterol in the Primary Prevention Group of

Prevention of coronary and stroke events with atorvastatin ...

The Role of Statins in Diabetes Treatment

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Efficacy and Safety of Atorvastatin in the Prevention of Cardiovascular End Points in Subjects With Type 2 Diabetes The Atorvastatin Study for Prevention of Coronary Heart Disease Endpoints in Non-Insulin-Dependent Diabetes Mellitus (ASPEN) ROBERT H. KNOPP, MD 1 MICHAEL D’EMDEN, MD 2 JOHAN G. SMILDE, MD, PHD 3 STUART J. POCOCK, PHD 4

The Role of Statins in Diabetes Treatment

Efficacy and Safety of Atorvastatin in the Prevention of ...

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Atorvastatin is a CYP3A4 substrate; telotristat ethyl is a CYP3A4 inducer. Temsirolimus: (Moderate) Monitor for an increase in atorvastatin-related adverse reactions if coadministration with temsirolimus is necessary. Atorvastatin is a P-glycoprotein (P-gp) substrate and temsirolimus is a P-gp inhibitor.

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The aim of the Collaborative Atorvastatin Diabetes Study (CARDS) was to assess the effectiveness of 10 mg of atorvastatin daily versus placebo in the primary prevention of cardiovascular disease in patients with type 2 diabetes. The trial was stopped 2 years earlier than planned because of significant benefit at the second interim analysis.

Lipitor (atorvastatin calcium) dose, indications, adverse ...

Primary prevention of cardiovascular disease with ...

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12/2/2018 · Atorvastatin is in a group of drugs called HMG CoA reductase inhibitors, or "statins." Atorvastatin reduces levels of "bad" cholesterol (low-density lipoprotein, or LDL) and triglycerides in the blood, while increasing levels of "good" cholesterol (high-density lipoprotein, or HDL).

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3/17/2015 · Further concerns about rosuvastatin’s renal effects were seen in an AstraZeneca funded randomized study comparing high dose rosuvastatin with atorvastatin in diabetic patients with progressive kidney disease.19 Although rosuvastatin lowered plasma lipid concentrations to a greater extent than atorvastatin, the study reported that ...

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We conducted a post hoc analysis to compare the efficacy and safety of atorvastatin among 1,129 patients aged 65-75 years at randomization with 1,709 younger patients in the Collaborative Atorvastatin Diabetes Study (CARDS).

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The objective of this study was to evaluate the safety and tolerability of atorvastatin 10 mg compared with placebo in 2,838 patients with type 2 diabetes and no history of coronary heart disease who were enrolled in the Collaborative Atorvastatin Diabetes Study (CARDS) and followed for 3.9 years.

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11/1/2006 · We conducted a post hoc analysis to compare the efficacy and safety of atorvastatin among 1,129 patients aged 65–75 years at randomization with 1,709 younger patients in the Collaborative Atorvastatin Diabetes Study (CARDS).

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The Collaborative Atorvastatin Diabetes Study (CARDS) recently established that treatment of type 2 diabetic patients with atorvastatin (10 mg daily) is effective in the primary prevention of CVD [7], with a 36% reduction in CHD events and a 48% reduction in stroke over the trial period.

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3/1/2009 · The Collaborative Atorvastatin Diabetes Study (CARDS)1 was a stunningly positive demonstration of the clinical benefit of statin therapy in patients with type 2 diabetes . In their analysis of the outcomes from CARDS, based on linear analysis, they determine the value of apolipoprotein B (apoB) that corresponds to target values of LDL ...

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• Overview of Basic Study Design and Biostatistics • Prominent Landmark Clinical Trials: – Statin trials – LDL-C focused nonstatin trials – Mixed lipid modification focused nonstatin trials – Triglyceride/HDL-C focused nonstatin trials • Other Landmark Trials • Trials on the Horizon 3

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al (9), and in our study, all patients were diabetic, whereas in the study by Ando et al (8), only four (11%) patients were diabetic. Studies comparing the effect of atorvastatin on circulating adiponectin levels in diabetic and nondiabetic patients are needed. To our knowledge, the present study is …

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