Combine study naltrexone

The COMBINE Study—

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The COMBINE study evaluated treatment response to novel medication and psychosocial treatment combinations for 1,383 alcohol-dependent, treatment-seeking patients from 11 US sites. What follows is a brief summary of the design and results of the COMBINE study.

The COMBINE Study—

COMBINE (Acamprosate/Naltrexone) - Full Text View ...

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9/12/2000 · Combine is a multicenter, randomized clinical trial that will evaluate combinations of three interventions for treating alcohol dependence. The goal is to determine whether improvement in treatment outcomes can be achieved by various combinations of drug and behavioral interventions. Two of the ...

COMBINE (Acamprosate/Naltrexone) - Full Text View ...

COMBINE Study | National Institute on Alcohol Abuse and ...

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The COMBINE Study (often times referred to as COMBINE) is the largest pharmacotherapy trial conducted for alcoholism in the United States, recruiting 1383 alcohol dependent patients, 31% women and 23% ethnic minorities, from 11 sites.

COMBINE Study | National Institute on Alcohol Abuse and ...

Combined pharmacotherapies and behavioral interventions ...

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5/3/2006 · Combined pharmacotherapies and behavioral interventions for alcohol dependence: the COMBINE study: a randomized controlled trial. Anton RF(1), O'Malley SS, Ciraulo DA, Cisler RA, Couper D, Donovan DM, Gastfriend DR, Hosking JD, Johnson BA, LoCastro JS, Longabaugh R, Mason BJ, Mattson ME, Miller WR, Pettinati HM, Randall CL, Swift R, Weiss RD ...

Combined pharmacotherapies and behavioral interventions ...

Overview of COMBINE - National Institutes of Health

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Overview of COMBINE ... The following sections summarize the nature of the treatments tested in COMBINE, the study design, and considerations for those contemplating use of the manuals. This information has been previously published in greater detail by the COMBINE Research Group. ... Each of the COMBINE medications, naltrexone and acamprosate ...

Overview of COMBINE - National Institutes of Health

CeDAR Education Article - Naltrexone and the COMBINE Study

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Evidence from the COMBINE study can help you get the most ‘Bang for the Buck’ in terms of addiction recovery care. Find out more about the COMBINE study and use the science to improve your health! You can conquer addiction. We can help you. CeDAR (720) 848-3000

CeDAR Education Article - Naltrexone and the COMBINE Study

The Most Effective Alcoholism Treatments Today

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11/11/2018 · Standing on the Shoulders of Giant Studies on Treatment of Alcohol Use Disorders. A massive study published in 2006 followed more than 1,300 study participants at 11 academic locations over a three-year period to determine what combination of treatment, medication, and counseling was the most effective for treating alcohol abuse disorders.

The Most Effective Alcoholism Treatments Today

Naltrexone for the treatment of alcohol dependence among ...

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yses of the COMBINE Study (COMBINE Study Research Group, 2003a,b) presented herein were designed to examine the effects of naltrexone among African Americans during the course of the 16-week treatment. 2. Methods 2.1. Participants and procedures The rationale and methods of the COMBINE Study have been described in detail

Naltrexone for the treatment of alcohol dependence among ...

The effects of naltrexone among alcohol non-abstainers ...

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The COMBINE Study was a large multi-site 16-week alco-hol dependence treatment study (see Materials and Methods for details). The main results from the COMBINE Study indicated that naltrexone was superior to no-naltrexone on a number of drinking outcome variables. The effects of naltrexone were in …

The effects of naltrexone among alcohol non-abstainers ...

ADAI Research: The COMBINE Study (NIAAA)

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The COMBINE Study, launched in 2001, is funded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA). ... Naltrexone, an opioid antagonist, interferes with brain neurotransmitter systems that produce pleasure, including the rewarding effects of alcohol.

ADAI Research: The COMBINE Study (NIAAA)

Naltrexone and acamprosate combination in alcohol ...

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Naltrexone and acamprosate combination in alcohol treatment. The use of Naltrexone and/or acamprosate can be helpful during alcohol treatment, however, to achieve the greatest success, individuals would benefit from incorporating psychological intervention.

Naltrexone and acamprosate combination in alcohol ...

Naltrexone for the treatment of alcohol dependence among ...

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12/1/2009 · In light of the literature on the pharmacogenetics of naltrexone, the analyses of the COMBINE Study (COMBINE Study Research Group, 2003a, COMBINE Study Research Group, 2003b) presented herein were designed to examine the effects of naltrexone among African Americans during the course of the 16-week treatment. 2. Methods2.1.

Naltrexone for the treatment of alcohol dependence among ...

COMBINED THERAPY: WHAT DOES ACAMPROSATE AND …

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Anton RF, Oroszi G, O'Malley S, Couper D, Swift R, Pettinati H, Goldman D. An evaluation of mu-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) study.

COMBINED THERAPY: WHAT DOES ACAMPROSATE AND …

COMBINE (Acamprosate/Naltrexone) - No Study Results Posted ...

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PDF | On Oct 1, 2006, Helen M Pettinati and others published The COMBINE Study-: An Overview of the Largest Pharmacotherapy Study to Date for Treating Alcohol Dependence

COMBINE (Acamprosate/Naltrexone) - No Study Results Posted ...

The COMBINE Study-: An Overview of the Largest ...

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5/2/2006 · The medication naltrexone and up to 20 sessions of alcohol counseling by a behavioral specialist are equally effective treatments for alcohol dependence when delivered with structured medical management, according to results from "Combining Medications and Behavioral Interventions for Alcoholism" (The COMBINE Study).

The COMBINE Study-: An Overview of the Largest ...

Naltrexone or Specialized Alcohol Counseling an Effective ...

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In the current manuscript we perform exploratory trajectory analyses to investigate the effects of naltrexone, acamprosate and the Combined Behavioral Intervention (CBI) in the COMBINE Study. The COMBINE Study (Anton et al., 2006) represents the largest study of pharmacotherapy for alcoholism in the United States.

Naltrexone or Specialized Alcohol Counseling an Effective ...

Naltrexone and combined behavioral intervention effects on ...

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PDF | These analyses of the COMBINE Study examined the effects of naltrexone among non-abstainers. Given that one of the most well-established mechanisms of action of naltrexone involves blunting ...

Naltrexone and combined behavioral intervention effects on ...

The Effects of Naltrexone Among Alcohol Non-Abstainers ...

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10/1/2008 · Background: This study investigated whether subgroups of alcohol-dependent patients responded differently to naltrexone versus placebo in the NIAAA COMBINE study. In particular, the A versus B and the Early Onset versus Late Onset typologies were examined. Relative to Type A alcoholics, Type B alcoholics are characterized by greater severity, earlier onset, stronger family …

The Effects of Naltrexone Among Alcohol Non-Abstainers ...

Effects of Alcoholism Typology on Response to Naltrexone ...

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COMBINE Monograph Series, Volume 2 (DHHS Publication No. 04-5289), National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 2004. Weiss RD, O'malley SS, Hosking JD, et al. Do patients with alcohol dependence respond to placebo? Results from the COMBINE Study. J Stud Alcohol Drugs 2008; 69:878. Finney JW, Hahn AC, Moos RH.

Effects of Alcoholism Typology on Response to Naltrexone ...

UpToDate

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The U.S. multisite COMBINE study, involving 1380 alcohol-dependent patients, found naltrexone, compared to placebo, to produce small but significant reductions in relapse to heavy drinking in patients receiving a medical-oriented behavioral intervention (Anton et al., 2006).

UpToDate

Naltrexone - an overview | ScienceDirect Topics

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Naltrexone was the first opiate-antagonist medication approved by the FDA for use in the treatment of alcoholism and opiate addiction. Some of the benefits of Naltrexone treatment are: Many patients experience dramatic reductions in cravings within hours of receiving their naltrexone. ... The COMBINE study was conducted at 11 academic sites ...

Naltrexone - an overview | ScienceDirect Topics

Naltrexone - Awakening Recovery Center

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Background: This study investigated whether subgroups of alcohol-dependent patients responded differently to naltrexone versus placebo in the NIAAA COMBINE study. In particular, the A versus B and the Early Onset versus Late Onset typologies were examined. Relative to Type A alcoholics, Type B alcoholics are characterized by greater severity, earlier onset, stronger family history, more ...

Naltrexone - Awakening Recovery Center

Effects of Alcoholism Typology on Response to Naltrexone ...

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10. What is the relationship of naltrexone to AA and other support groups? There is no contradiction between participating in support groups and taking naltrexone. In fact, one multisite study showed that naltrexone-taking subjects who attended mutual-support groups, such as AA, had better outcomes.

Effects of Alcoholism Typology on Response to Naltrexone ...

NIAAA Publications

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4/12/2010 · This short-term study, enlisting voluntary ambulatory patients seen at a substance-abuse treatment facility, bears repetition and extension to assess the replicability and sustainability of these reported benefits. How effective the treatments might be without CBT and the social aspects of the program is also unknown.

NIAAA Publications

Starting Treatment with Both Sertraline and Naltrexone for ...

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Answer: The COMBINE study was a large scale study in 2001 to test the effectiveness of pharmacotherapy in conjunction with psychological therapy for alcohol cessation. They found that naltrexone, combined behavioral intervention, or both improved outcomes for patients, while acamprosate did not improve alcohol cessation outcomes substantially.

Starting Treatment with Both Sertraline and Naltrexone for ...

What are the major findings of the COMBINE study? — Brain ...

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In summary, in a large study, we found no evidence that naltrexone combined with psychosocial therapy was an effective treatment for alcohol dependence. Our data raise doubts about the current use ...

What are the major findings of the COMBINE study? — Brain ...

Naltrexone in the Treatment of Alcohol Dependence | NEJM

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The medication naltrexone and up to 20 sessions of alcohol counseling by a behavioral specialist are equally effective treatments for alcohol dependence when delivered with structured medical management, according to results from "Combining Medications and Behavioral Interventions for Alcoholism" (The COMBINE Study).

Naltrexone in the Treatment of Alcohol Dependence | NEJM

Naltrexone or Specialized Alcohol Counseling an Effective ...

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Combining Medication and Behavioral Intervention in Treating Alcohol Dependence. The COMBINE Study was a multisite clinical trial sponsored by the National Institute on Alcohol Abuse and Alcoholism (NIAAA), to test whether combinations of medication and behavioral intervention would be more effective than monotherapies in the treatment of alcohol dependence.

Naltrexone or Specialized Alcohol Counseling an Effective ...

The Combine Study - Motivational Interviewing Online ...

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cards. Each capsule of naltrexone, gabapentin, or placebo also contained 100 mg of riboflavin. Participants were pro-vided up to 16 sessions of combined behavioral intervention therapy using the Combining Medications and Behavioral Interventions (COMBINE) study’s combined behavioral intervention treatment manual (25), which combined

The Combine Study - Motivational Interviewing Online ...

Gabapentin Combined With Naltrexone for the Treatment of ...

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METHODS The COMBINE Study Design The COMBINE Study tested combinations of two medications, naltrexone and acamprosate and two behavioral treatments, low-intensity medical management (MM) and moderately intensive combined behavioral intervention (CBI).

Gabapentin Combined With Naltrexone for the Treatment of ...

Relationship Between Medication Adherence and Treatment ...

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part because of naltrexone’s accumulated record of safety during extensive prior use for opioid detoxification and in the treatment of heroin addiction (Naltrexone… 1997; Miller 1997, p75). A deciding factor, however, was results from two pivotal stud­ ies demonstrating naltrexone’s usefulness as part of …

Relationship Between Medication Adherence and Treatment ...

ADDICTION TREATMENT Forum - SAMHSA

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Fill out our online form to request a PDF of the CeDAR Education Article - Alcohol and Its Effects: Naltrexone and the COMBINE Study. You can conquer addiction. We …

ADDICTION TREATMENT Forum - SAMHSA

Naltrexone and the COMBINE Study - cedarcolorado.org

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The Combined Pharmacotherapies and Behavioral Interventions (COMBINE) Study was designed to evaluate the efficacy of of medications, behavioral therapies, and their combination, for treating alcohol dependance. Naltrexone, behavioral therapy, and their combination were associated with …

Naltrexone and the COMBINE Study - cedarcolorado.org

Combined pharmacotherapies and behavioral interventions ...

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Patients with a certain gene variant drank less and experienced better overall clinical outcomes than patients without the variant while taking the medication naltrexone, according to an analysis of participants in the National Institutes of Health's 2001-2004 COMBINE (Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence) Study.

Combined pharmacotherapies and behavioral interventions ...

Gene Variant Predicts Medication Response in Patients with ...

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6/9/2011 · The COMBINE (Combining Medications and Behavioral Interventions for Alcoholism) study was able to show that using a medication such as naltrexone combined with some focused medical management could be an option to treat moderate to severe alcoholism in various health care settings.

Gene Variant Predicts Medication Response in Patients with ...

Combined Pharmacotherapies and Behavioral Interventions ...

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Mixed reviews o COMBINE Study Support for naltrexone in combination with from PSYCHOLOGY 162 at University of California, Los Angeles

Combined Pharmacotherapies and Behavioral Interventions ...

Mixed reviews o COMBINE Study Support for naltrexone in ...

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A meta-analysis of 2,861 patients in 24 combined randomized controlled trials (RCTs) demonstrated naltrexone to be an effective short-term (12 weeks) treatment for alcoholism, significantly decreasing relapses. 22 The large multisite COMBINE study (N = 1,383) showed that naltrexone, 100 mg/d, and medical treatment without behavioral treatment ...

Mixed reviews o COMBINE Study Support for naltrexone in ...

Medication for alcohol use disorder: Which agents work ...

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Naltrexone is an FDA approved prescription medicine that not only reduces or eliminates any desire for alcohol and drugs, but effectively blocks their effects as well. Can be very effective for: alcohol, heroin and all opioid drugs including Vicodin®, Oxycodone, Hydrocodone and many prescription pain medications.

Medication for alcohol use disorder: Which agents work ...

Naltrexone | IGotSober | Outpatient Alcohol & Treatment ...

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Naltrexone is a narcotic antagonist that has been shown to reduce alcohol craving and alcohol use in patients with alcohol dependence. It should not be used as exclusive treatment but only as an adjunct to a comprehensive program that includes psychologic and social treatment approaches such as those in Alcoholics Anonymous or professional programs.

Naltrexone | IGotSober | Outpatient Alcohol & Treatment ...
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